Researchers at the Department of Cell and Molecular Biology, Karolinska Institutet have captured the first detailed molecular ...

Scientists have identified a small flaw in the enzyme GPX4 that prevents neurons from defending themselves. This mutation, found in children with a rare form of early dementia, disrupts a tiny loop ...

Researchers at Nagoya University in Japan have identified two enzymes that are involved in macrophage polarization, one of the key factors affecting fibrosis. The group’s findings, reported in Cell ...

Once thought of as having one simple job within cells, researchers continue to learn more about the importance of organelles called lysosomes. An organelle is a small structure in a cell that is ...

A new artificial intelligence tool can predict the functions of enzymes based on their amino acid sequences, even when the enzymes are unstudied or poorly understood. Researchers said the AI tool, ...

Enzymes that cut DNA at specific sites are called endonucleases; these enzymes play many roles in genomic replication, fidelity, and defense. The initial discovery of restriction endonucleases in the ...

Cell death triggered by GPX4 loss was slowed in cell cultures and in mouse model using compounds that specifically inhibit ferroptosis.

Researchers at Helmholtz Munich, the Technical University of Munich and the LMU University Hospital Munich uncovered a ...

Researchers have identified how a single mutation in the GPX4 enzyme causes neurons to undergo ferroptosis, leading to severe early-onset dementia.

Why do nerve cells die in dementia - and can this process be slowed down? Researchers from the Technical University of Munich ...